Nano Medical Hydroxyapatite Technology and Fragment Characteristics
The APAGARD PREMIO toothpaste utilizes medical-grade nano hydroxyapatite (nano-mHAP) as its main active ingredient, consisting of crystalline calcium phosphate [Ca10(PO4)6(OH)2] particles manufactured at nanometer scale with typical diameter of 50-100 nanometers. This particle dimension enables penetration into enamel micropores and subsurface demineralized zones measuring 1-10 micrometers deepness, assisting in ionic bonding and crystal latticework combination with all-natural enamel framework making up around 96% hydroxyapatite by weight. The APAGARD Premio tooth paste 105g tube format supplies about 50-60 applications based upon suggested 1.5-2.0 gram dosage per cleaning session, keeping regular nano-mHAP focus throughout the product’s 36-month life span when kept at room temperature level (20-25 ° C). The APAGARD Premio tooth paste 3.7 oz volumetric specification corresponds to common 105-gram weight, with paste density of around 1.4 g/mL audit for combination of aqueous stage, humectants, and put on hold mineral bits.
Particle area steps 200-300 m TWO/ g, providing considerable responsive user interface for calcium and phosphate ion exchange with saliva and enamel substratum throughout regular 2-3 minute brushing period. The APAGARD PREMIO double mint toothpaste taste system uses menthol (0.3-0.5% by weight) and pepper mint oil (0.2-0.4%) for breath freshening while maintaining pH security between 6.5-7.5, crucial for protecting against nano-mHAP particle gathering below pH 6.0 or dissolution over pH 8.0. The APAGARD PREMIO fluoride totally free tooth paste solution addresses customer segments preventing fluoride because of oral fluorosis concerns in children or preference for biomimetic remineralization strategies, depending solely on nano-mHAP for enamel security without fluoride’s conversion of hydroxyapatite to fluorapatite [Ca10(PO4)6F2]
Remineralization Devices and Professional Efficacy Parameters
The APAGARD PREMIO nano hydroxyapatite toothpaste runs through three-phase mechanism: first bit adsorption onto enamel surface area via electrostatic destination happening within 30-60 secs of contact, diffusion into subsurface lesions over 1-2 min brushing duration, and continual mineral ion launch during 4-6 hour post-application period as bits gradually dissolve in acidic dental setting (pH 5.5-6.5). The APAGARD PREMIO nano mHAP tooth paste concentration of 10-12% by weight stands for costs formulation tier compared to conventional variations including 7-9% nano-mHAP, making it possible for increased remineralization kinetics for modest enamel demineralization situations. The APAGARD PREMIO enamel remineralization tooth paste achieves measurable enamel microhardness recuperation within 14 days of twice-daily application, with Vickers indentation testing at 200-gram load showing 15-25% solidity boost in artificially demineralized enamel over 28-day test periods.
Medical studies determining surface area roughness by means of atomic force microscopy reveal the APAGARD PREMIO enamel repair tooth paste minimizing enamel Ra values from common 0.8-1.2 micrometers in used enamel to 0.3-0.5 micrometers after 4 weeks of twice-daily usage. The APAGARD PREMIO all-natural whitening toothpaste achieves optical brightening with surface area smoothing rather than chemical bleaching, as nano-mHAP particles fill tiny surface area abnormalities that scatter occurrence light, raising specular representation coefficient from 15-25% (harsh enamel) to 40-55% (smooth enamel) without permeating enamel structure with oxidative processes. Checking electron microscopy imaging at 5,000-10,000 × zoom shows bit deposition filling up enamel surface problems, with energy-dispersive X-ray spectroscopy validating calcium-to-phosphate molar proportion of 1.65-1.67 matching stoichiometric hydroxyapatite structure.
Antimicrobial Characteristics and Biofilm Disturbance
The APAGARD PREMIO plaque removal toothpaste antimicrobial task derives from nano-mHAP’s adsorption of bacterial cells and proteins onto bit surface, reducing planktonic bacteria concentration in saliva by 30-50% and inhibiting biofilm formation via competitive surface area profession on enamel pellicle layer. The APAGARD PREMIO discolor control toothpaste rough system employs hydrated silica at 15-20% concentration with Relative Dentin Abrasivity (RDA) worth of 90-110, providing sufficient mechanical action for external stain removal from chromogenic compounds (coffee tannins, tea polyphenols, merlot anthocyanins) while staying listed below 150 RDA threshold related to too much enamel wear over prolonged use periods surpassing 5 years.
Flavor Chemistry and Sensory Characteristics
The APAGARD PREMIO breath freshening tooth paste volatile compound profile includes menthol, eucalyptol, and thymol at consolidated focus of 0.5-0.8%, supplying prompt breath refreshing with unpredictable organic substance variation of malodorous sulfur substances (hydrogen sulfide, methyl mercaptan) produced by anaerobic bacterial metabolic rate. The APAGARD PREMIO tooth cavity protection toothpaste ideal application procedure specifies 0.8-1.0 gram dose applied to soft-bristle toothbrush with bristle size 0.15-0.20 mm, using modified Bass method with 45-degree bristle angle to gingival margin, circular movement covering 2-3 teeth per area, and 2-3 min total brushing duration maintaining pressure below 150 grams to avoid enamel abrasion.
The APAGARD PREMIO mild tooth paste for families security profile throughout age ranges comes from nano-mHAP’s biocompatibility, as ingested particles undergo dissolution in gastric acid (pH 1.5-3.5) launching calcium and phosphate ions that the body procedures through regular mineral homeostasis paths without systemic poisoning concerns. The APAGARD PREMIO tooth paste for sensitive teeth addresses dentin hypersensitivity with nano-mHAP bit deposition within subjected dentin tubules measuring 1-3 micrometers size, literally occluding tubule openings and lowering hydraulic conductance by 60-80% within 2 week of twice-daily application as gauged by fluid circulation researches. Those that acquire APAGARD PREMIO toothpaste get formulation preserving nano-mHAP suspension stability with xanthan gum (0.5-1.0%) providing thixotropic residential or commercial properties that facilitate particle resuspension through tube pressing action. Those who get APAGARD PREMIO tooth paste 105g get around 50-60 applications making it possible for constant remineralization impact throughout the 4-8 week duration required for measurable enamel microhardness recovery.
Daily Application Procedures and Long-Term Maintenance
The APAGARD PREMIO tooth paste for day-to-day enamel treatment maintenance regimen needs twice-daily application adhering to dishes when salivary pH goes down to 5.5-6.0 as a result of bacterial acid manufacturing from nutritional carb metabolic rate, producing demineralization problems where enamel loses calcium and phosphate ions. The APAGARD PREMIO tooth paste with nano mHAP for enamel support particle focus allows measurable surface microhardness recuperation as deposited particles gradually liquify in acidic oral setting providing sustained mineral ion release during neutral pH healing durations. The APAGARD PREMIO toothpaste for enamel conditioning system increases enamel microhardness by 15-25% over 28-day application period with indentation deepness decreasing from 80-100 micrometers in demineralized enamel to 60-75 micrometers in cured enamel as verified by laboratory screening procedures.
The APAGARD PREMIO toothpaste for smooth enamel really feel surface texture alteration lowers enamel roughness from 0.8-1.2 micrometers in used enamel to 0.3-0.5 micrometers after 4 weeks of twice-daily use, approaching the 0.1-0.2 micrometer Ra worths of intact enamel surface area. The APAGARD PREMIO tooth paste for tarnish control and lightening combines mechanical tarnish elimination through moisturized silica abrasive with optical lightening up from surface smoothing, eliminating microscale attributes that scatter incident light without modifying intrinsic tooth color via chemical lightening procedures. The APAGARD PREMIO toothpaste for fresh breath and tidy teeth flavor persistence prolongs 2-4 hours post-brushing via recurring menthol and pepper mint oil elements sticking to oral mucosa with gradual release keeping fresh taste assumption.
Formulation Stability and Storage Requirements
The APAGARD PREMIO toothpaste for plaque control rheological residential properties display shear-thinning behavior with viscosity decreasing from 100,000 cP at rest to 5,000-10,000 cP under brushing shear rates (100-1000 s ⁻¹), promoting brush loading and interdental penetration. The APAGARD PREMIO toothpaste for mild household cleaning salt lauryl sulfate web content (1-2%) supplies surfactant activity for particles elimination while staying below concentrations above 2.5% associated with dental mucosa irritability in sensitive people or little ones. The APAGARD PREMIO tooth paste for sensitive teeth and enamel treatment dual-action strategy addresses both hypersensitivity with tubule occlusion and enamel demineralization through mineral replacement, ideal for individuals experiencing multiple concurrent conditions affecting 10-30% of adult populace.
The APAGARD PREMIO tooth paste with double mint flavor employs menthol’s modest lipophilicity (log P = 3.4) making it possible for dividing into oral mucosa lipid bilayers with steady launch extending taste perseverance. The APAGARD PREMIO fluoride free tooth paste for daily usage preservative system uses sodium benzoate (0.1-0.3%) keeping microbiological stability with microbial count listed below 10 CFU/g over 36-month storage space period meeting pharmaceutical-grade requirements. The APAGARD PREMIO nano hydroxyapatite toothpaste 105g tube packaging utilizes aluminum-plastic laminate building and construction avoiding moisture loss and keeping paste consistency over product life expectancy. Extra technical specs and application advice are readily available at http://theapagard.com/ for users requiring detailed info on nano-mHAP remineralization innovation and optimum brushing protocols.