Nano Medical Hydroxyapatite Bit Innovation and Dentin Tubule Occlusion
The APAGARD PREMIO tooth paste for delicate teeth addresses dentin hypersensitivity via nano-mHAP fragment deposition within exposed dentin tubules gauging 1-3 micrometers in size, which link pulp chamber nerve endings to dental setting. When enamel wears down or gingival economic downturn exposes dentin, liquid movement within these tubules causes mechanoreceptor activation, creating acute pain action to thermal, osmotic, or tactile stimulations. Nano hydroxyapatite fragments at 50-100 nanometer size physically occlude tubule openings through rainfall and crystal growth, lowering hydraulic conductance by 60-80% within 2 week of twice-daily application as measured by liquid circulation research studies utilizing pressurized dye penetration approaches.
Those that get APAGARD PREMIO tooth paste receive solution consisting of 10-12% medical-grade nano-mHAP by weight, standing for premium concentration rate compared to typical 7-9% versions. This elevated particle thickness speeds up tubule occlusion kinetics and offers enhanced enamel remineralization capability for users experiencing moderate demineralization from dietary acid direct exposure (citric acid from fruits, acetic acid from vinegar-based foods, carbonic acid from carbonated beverages). Those that order APAGARD PREMIO tooth paste 105g obtain approximately 50-60 applications based upon advised 1.5-2.0 gram dosage per brushing session, with tube product packaging utilizing aluminum-plastic laminate building and construction preventing moisture loss and maintaining paste uniformity over 36-month service life at room temperature storage (20-25 ° C).
Daily Enamel Maintenance Protocols and Remineralization Kinetics
The APAGARD PREMIO toothpaste for daily enamel treatment upkeep routine needs twice-daily application complying with dishes when salivary pH goes down to 5.5-6.0 as a result of bacterial acid manufacturing from nutritional carbohydrate metabolic rate, creating demineralization conditions where enamel loses calcium and phosphate ions. Nano-mHAP bits in the solution adsorb onto enamel surface area with electrostatic tourist attraction within 30-60 secs of call, after that diffuse right into subsurface lesions determining 10-50 micrometers depth over 2-3 minute brushing duration. The APAGARD PREMIO tooth paste with nano mHAP for enamel support bit surface of 200-300 m TWO/ g supplies substantial reactive surface area for calcium and phosphate ion exchange, with ions precipitating as crystalline hydroxyapatite [Ca10(PO4)6(OH)2] that incorporates into existing enamel crystal latticework structure.
The APAGARD PREMIO toothpaste for enamel strengthening system increases enamel microhardness by 15-25% over 28-day application duration as gauged by Vickers imprint screening at 200-gram tons, with indentation depth lowering from 80-100 micrometers in demineralized enamel to 60-75 micrometers in cured enamel. X-ray diffraction evaluation validates deposited material suits stoichiometric hydroxyapatite crystalline structure with calcium-to-phosphate molar ratio of 1.67, showing complete mineral integration as opposed to surface layer that would wash away with saliva circulation. The APAGARD PREMIO tooth paste for smooth enamel really feel surface texture adjustment decreases enamel roughness (Ra) from 0.8-1.2 micrometers in used enamel to 0.3-0.5 micrometers after 4 weeks of twice-daily usage, as determined by atomic pressure microscopy scanning 50 × 50 micrometer surface at 512 × 512 pixel resolution.
Surface Roughness Decrease and Optical Reflectance Properties
The APAGARD PREMIO toothpaste for tarnish control and bleaching optical lightening up arise from nano-mHAP loading tiny surface area irregularities that spread case light, enhancing specular representation coefficient from 15-25% (harsh enamel) to 40-55% (smooth enamel) without chemical lightening agents like hydrogen peroxide or carbamide peroxide. Surface area smoothing happens with advantageous deposition in surface area valleys and defects, with bit adhesion more powerful in low-energy surface area areas compared to increased areas experiencing higher shear forces from saliva circulation and tongue contact. The APAGARD PREMIO toothpaste for fresh breath and clean teeth includes moisturized silica abrasive at 15-20% concentration with Family member Dentin Abrasivity (RDA) value of 90-110, giving adequate mechanical action for external tarnish elimination from chromogenic substances (coffee tannins, tea polyphenols, red wine anthocyanins) while remaining listed below 150 RDA threshold associated with excessive enamel wear.
Plaque Biofilm Interruption and Antimicrobial Devices
The APAGARD PREMIO tooth paste for plaque control lowers bacterial bond to enamel surface area with affordable line of work, as nano-mHAP bits adsorb to enamel pellicle layer (0.1-1.0 micrometer thick protein movie) before bacterial emigration happens. Particle surface area charge at pH 6.5-7.5 exhibits minor unfavorable zeta potential (-10 to -15 mV) allowing electrostatic repulsion of negatively charged bacterial cell wall surfaces, lowering Streptococcus mutans and Porphyromonas gingivalis attachment by 40-60% contrasted to unattended enamel surface areas in vitro bacterial attachment assays. The APAGARD PREMIO tooth paste for gentle family members cleaning formula maintains salt lauryl sulfate focus at 1-2% to provide surfactant activity for particles elimination while staying clear of focus over 2.5% connected with oral mucosa irritation in sensitive people or kids.
The APAGARD PREMIO tooth paste for sensitive teeth and enamel treatment dual-action method addresses both hypersensitivity with tubule occlusion and enamel demineralization via mineral replacement, making it suitable for users experiencing numerous concurrent problems. Dentin hypersensitivity affects 10-30% of adult population and regularly accompanies enamel put on from erosive problems (gastroesophageal reflux, frequent citrus usage) or abrasive cleaning practices using hard-bristle tooth brushes with too much force above 200 grams.
Flavor System and Organoleptic Characteristics
The APAGARD PREMIO tooth paste with double mint taste uses menthol (0.3-0.5% by weight) and pepper mint oil (0.2-0.4%) giving cooling feeling with TRPM8 receptor activation in trigeminal nerve endings, developing assumption of temperature level decrease without real thermal adjustment. Flavor determination prolongs 2-4 hours post-brushing through menthol’s modest lipophilicity (log P = 3.4) making it possible for partition into dental mucosa lipid bilayers with gradual release. Sweetening system makes use of sorbitol (40-50% concentration) operating as both humectant keeping 25-30% water material in paste and supplying wonderful taste without cariogenic capacity, as oral germs can not metabolize sorbitol to lactic acid under normal pH conditions. The APAGARD PREMIO fluoride cost-free toothpaste for day-to-day usage targets customers staying clear of fluoride because of dental fluorosis worries in little ones (ages 0-6 years) where too much fluoride consumption during enamel growth triggers subsurface hypomineralization, or people liking biomimetic remineralization techniques over fluoride’s device of fluorapatite [Ca10(PO4)6F2] formation.
Formula Rheology and Application Specifications
The APAGARD PREMIO nano hydroxyapatite toothpaste 105g tube paste displays non-Newtonian shear-thinning actions with obvious thickness of 100,000 centipoise at rest (0.1 s ⁻¹ shear price) reducing to 5,000-10,000 cP under cleaning problems (100-1000 s ⁻¹ shear rate), helping with brush loading and interdental infiltration. Thixotropic buildings originate from xanthan gum (0.5-1.0%) producing short-lived network structure that damages under shear tension and restores at rest, stopping fragment settling during storage space while allowing flow throughout giving. Optimal application procedure specifies 0.8-1.0 gram dosage applied to soft-bristle tooth brush (bristle diameter 0.15-0.20 mm) with changed Bass technique: 45-degree bristle angle to gingival margin, little circular motions covering 2-3 teeth per location, 2-3 min overall period maintaining brushing force listed below 150 grams to stop enamel abrasion.
pH buffer system utilizes sodium phosphate keeping pH 6.5-7.5 throughout life span, avoiding nano-mHAP bit gathering below pH 6.0 or dissolution over pH 8.0 that would compromise efficiency. Fragment dimension distribution keeps median size 80-100 nanometers with coefficient of variant below 15% via regulated wet-milling synthesis process, ensuring consistent remineralization kinetics throughout production sets. Preservative system uses salt benzoate (0.1-0.3%) keeping microbiological security with bacterial matter listed below 10 CFU/g over 36-month storage, meeting pharmaceutical-grade requirements for dental treatment items. Post-brushing method advises expectoration without water washing to maintain raised calcium and phosphate ion concentration in saliva from recurring nano-mHAP fragments, extending remineralization task into 4-6 hour period adhering to application when fragment dissolution in acidic dental setting (pH 5.5-6.5) supplies sustained mineral ion release.